Turmeric w/ Bioperine
BioPerine® is a patented extract obtained from black pepper fruits (Piper nigrum) standardized minimum to 95% Piperine, marketed by Sabinsa Corporation and has been used as a bioavailability enhancer for more than 20 years. BioPerine® has the remarkable ability to increase the bioavailability of co-administered nutrients. Different mechanisms of bio-enhancing activity of BioPerine® have been proposed:
- BioPerine® modulates the enzymes responsible for metabolizing nutritional substances
- It stimulates the activity of amino-acid transporters in the intestinal lining
- It inhibits p-glycoprotein, the 'pump' protein that removes substances from cells
- It decreases the intestinal production of glucuronic acid and reduces the activity of glucuronyl transferase enzyme thereby permitting more of the substances to enter the body in their active form
BioPerine® supplementation can turn a marginally effective nutritive substance into a highly effective one by increasing its bioavailability and intracellular residence time. A good example of this phenomenon is the use of BioPerine® to increase the bioavailability of curcumin, a supplement with broad beneficial health effects on joints, inflammatory disorders, activity against cancers, metabolic disorders and infections.