Turmeric w/ Bioperine

BioPerine^® is a patented extract obtained from black pepper fruits (Piper nigrum) standardized minimum to 95% Piperine, marketed by Sabinsa Corporation and has been used as a bioavailability enhancer for more than 20 years. BioPerine^® has the remarkable ability to increase the bioavailability of co-administered nutrients. Different mechanisms of bio-enhancing activity of BioPerine^® have been proposed:

1. BioPerine^® modulates the enzymes responsible for metabolizing nutritional substances
2. It stimulates the activity of amino-acid transporters in the intestinal lining
3. It inhibits p-glycoprotein, the 'pump' protein that removes substances from cells
4. It decreases the intestinal production of glucuronic acid and reduces the activity of glucuronyl transferase enzyme thereby permitting more of the substances to enter the body in their active form

BioPerine^® supplementation can turn a marginally effective nutritive substance into a highly effective one by increasing its bioavailability and intracellular residence time. A good example of this phenomenon is the use of BioPerine^® to increase the bioavailability of curcumin, a supplement with broad beneficial health effects on joints, inflammatory disorders, activity against cancers, metabolic disorders and infections.